Fikadu Tafesse

This study identifies Synaptotagmin 1 and 7 as facilitators of MR1-mediated antigen presentation of Mycobacterium tuberculosis to MAIT cells.

This study identifies diacylglycerol (DAG) as critical for phagocytosis of M. tuberculosis, showing that DAG disruption reduces uptake without affecting receptor trafficking or cargo binding.

This study shows that mutations in MR1 outside the antigen binding groove differentially affect exogenous antigen presentation by altering B2M association.

This study develops domain-specific nanobodies that inhibit SARS-CoV-2 infection by disrupting N protein phase separation and replication.

This paper describes a protocol for profiling lipid-protein interactions using multifunctional lipid probes and provides methods for conjugate preparation and proteomic analysis.

This study develops a high-affinity anti-MR1 nanobody that selectively inhibits MR1-restricted T cell activation, providing insights into MR1 function and a tool for immunological research.

The paper investigates factors regulating HIV-1 fusion in reverse, finding that Env activity depends on cell surface levels, is inhibited by a fusion inhibitor, and is influenced by lipid membrane composition.

The paper describes a method using biolayer interferometry to measure nanobody binding kinetics and perform competition-based epitope mapping.

This paper shows that lentiviruses decorated with a nanobody targeting SARS-CoV-2 Spike selectively infect Spike-expressing cells and can deliver cargo to infected cells.

The paper synthesizes three palmitic acid derivatives with diazirine at different positions and shows that end-position diazirines crosslink distinct protein subsets.

The paper systematically analyzes the sphingomyelin synthase family in C. elegans, identifying three SM synthases and one CPE synthase with distinct subcellular distributions.