Author
Caroline S. Hill
The Francis Crick InstituteORCID 0000-0002-8632-0480Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2022-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 18 mutual co-author links6 papers
Recent·Most cited
- BioengineeringbioRxivPreprint
Pro-domain-dependent folding and co-receptor-mediated targeting to optimize an antagonistic TGF-β monomer for gene-based delivery
Łukasz Wieteska, Cynthia S. Hinck, Ananya Mukundan…·Andrew P. Hinck
This paper improves the folding and targeting of an engineered TGF-β monomer for gene-based delivery by modifying its pro-domain and adding a CD44 binding domain.
DOI 10.64898/2026.03.23.713733 - Cancer BiologybioRxivPreprint
Anti-activin treatment increases T cell infiltration in breast and pancreatic tumours and promotes survival in a SMAD4-null mouse pancreatic cancer model
Simon J. McCluney, Danielle Park, Daniel S.J. Miller…·Caroline S. Hill
This study shows anti-activin treatment reduces desmoplastic barriers and increases T cell infiltration in tumors, improving survival in SMAD4-null pancreatic cancer models.
1 citation - BiophysicsNature CommunicationsPeer-reviewed
Structures of TGF-beta with betaglycan and the signaling receptors reveal the mechanism whereby betaglycan potentiates receptor complex assembly and signaling
Łukasz Wieteska, Alexander B. Taylor, Emma K. Punch…·Andrew P. Hinck
This study determines the structure of TGF-beta bound to betaglycan and its signaling receptors, revealing mechanisms of ligand selectivity and signal potentiation.
33 citationstop 1% - Developmental BiologyDevelopmental CellPeer-reviewed
Nodal signaling establishes a competency window for stochastic cell fate switching
Andrew D. Economou, Luca Guglielmi, Philip East, Caroline S. Hill
The paper shows that Nodal signaling creates a temporal window for stochastic cell fate switching in zebrafish embryos, challenging deterministic models of morphogen action.
- Developmental BiologybioRxivPreprint
An improved Erk biosensor reveals oscillatory Erk dynamics driven by mitotic erasure during early development
Scott G. Wilcockson, Luca Guglielmi, Pablo Araguas Rodriguez…·Caroline S. Hill
The paper introduces an improved Erk biosensor to study Erk signaling dynamics in zebrafish and Drosophila embryos, revealing oscillatory dynamics driven by mitotic erasure.
6 citations