Robert P. Fagan

The paper investigates the structural organization and assembly of the bacterial spore envelope in Clostridium sporogenes, revealing common principles of crystalline and disulphide-based self-assembly across distantly related bacteria.

This paper identifies two point mutations in a two-component system that confer vancomycin resistance in C. difficile, revealing a synergistic pathway for resistance in epidemic strains.

This study shows that C. difficile can evolve vancomycin resistance through two pathways, but resistance comes with fitness costs and sporulation defects that may limit its clinical impact.