Swati S. More

This study identifies ROS-DPCs in human cells and shows that the ubiquitin-proteasomal system, SPRTN, and NER remove them, with a GSH analog preventing their formation.

This study identifies the N-terminal catalytic domain of ACE as the primary site for endogenous opioid peptide degradation in brain tissue and shows that inhibiting this domain reduces opioid degradation.

The paper identifies ACE inhibitors that enhance endogenous opioid signaling by reducing enkephalin degradation, showing analgesic effects in vivo.

This study shows that loss of RBPR2 affects retinoid homeostasis and visual pigment synthesis, leading to visual function defects in mice under vitamin A deficiency.

This paper evaluates a prodrug of a glutathione surrogate in an Alzheimer's mouse model, showing it reduces oxidative stress, amyloid pathology, and neurodegeneration while identifying metabolic biomarkers.

This study shows that deleting Glyoxalase 1 worsens acetaminophen-induced liver damage in mice by increasing oxidative stress and necrosis.

This paper develops PSA inhibitors to prolong enkephalin stability and reduce pain, showing analgesic effects in vivo and confirming their mechanism through pharmacokinetics and modeling.

This study shows that ACE inhibition enhances endogenous opioid signaling and reduces fentanyl-induced conditioned place preference in mice.