E. Camilla Forsberg

This study shows that aging-specific megakaryocyte progenitors have increased mitochondrial capacity, contrasting with aged hematopoietic stem cells, and that enhancing mitochondrial activity affects platelet production differently in young and old mice.

The paper identifies a rare HSC-derived megakaryocyte progenitor that accumulates with age, contributing to exaggerated thrombopoiesis and age-related platelet-mediated morbidities.

This paper identifies an age-specific platelet differentiation pathway from hematopoietic stem cells that contributes to thrombosis and platelet hyperreactivity in aging.

Tn5Prime is a 5' capture method for RNA-seq that enables accurate transcription start site identification and transcriptome quantification in single cells and bulk samples.

The paper uses long-read RNAseq to identify and quantify complex isoforms in individual B cells, revealing widespread transcriptional variation in surface receptors and the antibody heavy chain locus.