Leslie M. Baehr

This study investigates how UBR-box E3 ubiquitin ligases respond to changes in protein synthesis and skeletal muscle size, finding increased abundance and activity of these ligases under conditions of muscle growth and regeneration.

This study identifies Txlnb as a centrosome-adapter protein that mediates proteostasis in cardiomyocytes, linking centrosomes to the ubiquitin-proteasome system and influencing cardiac stress responses.

This study identifies UBE2 family members that interact with MuRF1 to mediate ubiquitylation, revealing a two-step mechanism for mono- and poly-ubiquitin chain formation.