Yannick Brüggemann

This study uses a chemical-optogenetic approach to control β-catenin activity in mouse small intestinal organoids, revealing persistent aberrant phenotypes and altered differentiation during homeostasis.

This study compares antiviral and cytolytic responses in primary human hepatocytes to YFV vaccine and virulent strains, finding similar propagation kinetics but distinct transcriptional responses.

This study identifies lysosomal cathepsins, particularly CTSL, as critical for HEV entry and demonstrates the antiviral efficacy of the pan-cathepsin inhibitor K11777.

This study identifies cell culture adaptive mutations in HCV that enhance replicative fitness in cell lines but reduce virion production in primary human hepatocytes by boosting antiviral responses.

The paper identifies how EGFR interacts with PTPs on juxtaposed membranes to create a network that senses and responds to growth factor signals.