Brigitte Lina Kieffer

This study shows GPR88 localizes to primary cilia in specific neuronal cell types in the striatum and somatosensory cortex.

This study identifies sex-specific epigenetic changes in the nucleus accumbens of male and female mice exposed to chronic morphine, revealing shared biological dysregulation and potential therapeutic targets.

The paper identifies nucleus accumbens inhibitory interneurons as a key site where mu opioid receptor expression promotes social behavior, distinct from its role in exogenous opioid sensitivity.

This study introduces a CRISPR-based Oprm1-Cre knock-in rat to investigate the role of nucleus accumbens MOR-expressing cells in heroin self-administration, finding sex-specific effects on acquisition and effort.

The paper shows that MHb-MOR neurons promote negative affect through distinct projection pathways to the IPN and DRN, revealing two routes for aversion and anxiety.

The paper compares structural and functional brain connectivity between C57BL/6 and BALB/cJ mice using MRI techniques, revealing strain-specific differences in brain morphology and connectivity patterns.

The paper investigates increased mu opioid receptor (MOR) functional coupling in the anterior insula of depressed individuals, linking it to increased expression of the inhibitory G-protein subunit GNAI2.

This study shows that knocking down hypocretin/orexin in rats reduces cocaine self-administration during extended access, suggesting a role in compulsive drug-taking behavior.