Nagarajan Kannan

This study identifies nuclear cathepsin L (nCTSL) as a biomarker for PARP inhibitor sensitivity in ovarian cancer and shows that combining clofarabine with PARP inhibitors enhances therapeutic response.

This paper presents a single-cell RNA sequencing atlas of the adult human male breast, revealing distinct transcriptional properties and composition compared to female breast tissue.

The paper identifies a rare multipotent epithelial cell in the fallopian tube as a potential cell-of-origin for high-grade serous ovarian cancer using multi-omic profiling and organoid models.

This study identifies cKIT as a key mediator of oxidative signaling in human mammary luminal progenitor cells and links its activation to poor outcomes in basal-like breast cancers.

The paper establishes a salivary regenerative biobank and identifies markers and proteomic signatures of salivary gland stem and progenitor cells.

The paper identifies an epigenetic signature associated with persister tumor cells in ovarian cancer that correlates with chemotherapy resistance and defines the persister state.

The paper shows that asexual haploid blastocyst fitness varies across mouse strains, with selectively-inbred mice showing higher success rates in generating haploid blastocysts compared to outbred mice.

The paper analyzes the impact of puberty blockers on testicular cell states and function using single-cell RNA sequencing and clinical data from PB-treated children.