Author
F. Hoffmann-La Roche AGORCID 0000-0002-8918-1869Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Ryo Okuda, Christoph Harmel, Quan Xu…·J. Gray Camp
The paper introduces a platform for high-throughput spatial phenotyping of multilineage organoids, identifying pathway modulators and treatment strategies for PDAC.
Matthias Höllerhage, Linghan Duan, Oscar Wing Ho Chua…·Günter U. Höglinger
The paper identifies SNX5 knockdown as protective against alpha-synuclein toxicity in a Parkinson's disease cell model through genome-wide RNA interference screening.
Hiroyuki Uechi, Sindhuja Sridharan, Jik Nijssen…·Richard John Wheeler
The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.
Rubén López-Sandoval, Marius F. Harter, Qianhui Yu…·J. Gray Camp
The paper develops engineered human gut tissues to study host-microbe interactions and identifies an epithelial gene regulatory network in response to Salmonella Typhimurium infection.
Said el Bouhaddani, Matthias Höllerhage, Hae‐Won Uh…·Jeanine J. Houwing‐Duistermaat
The paper presents a computational workflow integrating multi-omics and drug screening data from cell lines to identify druggable pathways in synucleinopathies.
Juliana G. Roscito, Katrin Sameith, Genı́s Parra…·Michael Hiller
The paper shows that loss of morphological traits in snakes and subterranean mammals is linked to widespread divergence of regulatory elements associated with those traits.