Jordi Planells

This study shows neural stem cells can maintain function outside their normal anatomical niche, revealing plasticity in stem-cell environment relationships.

This paper shows that DIS3's 3-5 exoribonuclease activity degrades backtracked RNA, resolving stalled RNAPII complexes and enabling transcription elongation.

This study shows eIF5A coordinates gene expression by repressing transcription of its target genes in the nucleus while promoting their translation in the cytoplasm.

This study shows TET2 regulates 5hmC deposition in adult neural stem cells, balancing stemness and differentiation through distinct epigenetic programs.

The paper shows that TET3 protects the Dlk1-Dio3 imprinted locus from hypomethylation during iPSC reprogramming from neural stem cells.

The paper analyzes genomic imprinting changes during reprogramming of adult neural stem cells into iPSCs, identifying transcriptome and methylation alterations linked to pluripotency and epigenetic quality.

The paper genetically inactivates HSF1 in yeast to show it uniquely senses protein misfolding and triggers a specific transcriptional stress response, distinct from heat shock.

The paper shows the exosome degrades chromatin-associated RNAs and helps maintain chromatin homeostasis by regulating repetitive sequences and centromere organization.