Marie A. Floryan

The paper introduces IntravChip, a microfluidic platform to study tumor cell intravasation and collect intravasated cells, showing it can quantify intravasation rates and test anti-metastatic drugs.

This study develops an optical system to measure perfusion pressure and flow resistance in microfluidic devices without contacting the fluid, validating its accuracy against hydrostatic methods.

This study generates functional endothelial cells from human iPSCs using ETV2 overexpression, enabling the creation of vascularized microphysiological models.

This study shows that long-term flow can maintain and remodel microvascular networks in a microphysiological system for 51 days, reducing inflammation and enabling vascular remodeling.

The paper develops engineered microvascular networks with a KLF2 reporter to study flow effects on vascular structure and function, finding increased KLF2 expression correlates with larger vessel diameters and improved barrier function.