Guillermo García‐Cardeña

This study maps the transcriptional landscape of the rat cardiovascular system at single-cell resolution, identifying 26 cell types and revealing tissue-specific molecular diversity and communication networks.

The paper develops engineered microvascular networks with a KLF2 reporter to study flow effects on vascular structure and function, finding increased KLF2 expression correlates with larger vessel diameters and improved barrier function.

The paper uses single-nuclei RNA-seq and spatial transcriptomics to analyze gene expression changes in the right atrium of patients with ischemic heart disease, revealing inflammatory microvascular dysfunction and altered tissue composition.

The paper identifies Plexin-D1 as a mechanosensor that regulates Dorsal Aorta caliber through KLF2-mediated endothelial cell enlargement.