Matthew D. Dun

This paper evaluates the combination of B7-H3 CAR T cells and ONC206 against DIPG models, showing enhanced anti-tumor efficacy in vitro and in vivo.

This study identifies extensive phosphoproteomic remodeling in mouse sperm during maturation and capacitation, revealing key kinases and their roles in fertility.

This study shows that hypomethylating agents induce epigenetic and transcriptional heterogeneity in AML cells, with some cells retaining methylation and showing increased self-renewal, and identifies statins as a potential co-treatment to enhance HMA efficacy.

The paper uses multiplexed immunofluorescence and AI models to analyze the tumor microenvironment of diffuse midline glioma and predict antigens from H&E staining.

This study shows that sub-chronic heat stress alters sperm small non-coding RNA profiles in mice, leading to accelerated embryonic development and fetal weight gain.

This study identifies ATM-driven DNA repair and ROS addiction as mechanisms of resistance to FLT3 inhibitors in AML and shows ATM inhibition can overcome resistance in vitro and in vivo.

The paper introduces scTEM-seq to profile DNA methylation and transcriptomes in single cells, finding DNA methylation heterogeneity linked to gene expression and transposable element activity in AML cells.