Heather J Lee

The paper examines DNA methylation dynamics in marsupial embryos, finding global demethylation in the trophectoderm but not the embryonic lineage, suggesting 5mC erasure in extraembryonic tissue is ancestral in therian mammals.

This study shows that hypomethylating agents induce epigenetic and transcriptional heterogeneity in AML cells, with some cells retaining methylation and showing increased self-renewal, and identifies statins as a potential co-treatment to enhance HMA efficacy.

This study shows testicular hyperthermia rapidly reduces piRNA levels and increases LINE1 activity in male germ cells, leading to DNA damage and potential infertility.

This study shows hypoxia reduces the effectiveness of hypomethylating agents in AML cells by altering DNA methylation and antigen presentation pathways.

This study shows maternal SMCHD1 is essential for imprinted Xist expression and X chromosome inactivation in mouse embryos and placenta.

The paper introduces scTEM-seq to profile DNA methylation and transcriptomes in single cells, finding DNA methylation heterogeneity linked to gene expression and transposable element activity in AML cells.

This study identifies Smchd1 as a maternal effect gene that regulates imprinted expression of 16 genes by translating polycomb-mediated histone methylation marks into a heritable chromatin state.

The paper shows that during exit from pluripotency, coexpression of DNMT3s and TETs drives genome-scale DNA methylation oscillations, with amplitude dependent on CpG density, observed both in vitro and in vivo.

This paper introduces scNMT-seq, a method for joint profiling of chromatin accessibility, DNA methylation, and transcription in single cells, and validates it in differentiating mouse embryonic stem cells.

This paper introduces DeepCpG, a deep learning method to predict single-cell DNA methylation states from sequence and incomplete profiles, showing improved accuracy over existing methods.

The paper tracks the transition of mouse embryonic stem cells from ground state pluripotency to a formative phase, showing acute exit from naive status and transcriptome changes similar to early post-implantation epiblast.