Ivan K. H. Poon

This study identifies a new apoptotic morphology, AsyCDM, where apoptotic cells asymmetrically partition nuclear material into apoptotic bodies via ROCK1-dependent actomyosin contraction.

This study shows that apoptotic dendritic cells release large extracellular vesicles called apoptotic bodies that can directly present antigens and modulate immune responses.

The paper identifies a novel naphthyridone inhibitor of PANX1 with reduced off-target effects, showing efficacy in a mouse model of IBD.

This study shows that T-type calcium channel blockers reduce SARS-CoV-2 spread via apoptotic bodies and limit cytokine storms in macrophages.