Zhaozhu Qiu

This study identifies SWELL1-mediated D-2HG export as a mechanism for immune evasion and metabolic fitness in IDH-mutant gliomas, showing that inhibiting this pathway can suppress tumor growth and enhance immune response.

This study identifies KAT7 as an epigenetic regulator that drives microglial mitochondrial immunity and Alzheimer's disease pathogenesis by enhancing mtDNA-driven inflammation and amyloid-β burden.

This study identifies PSA as an inhibitory auxiliary subunit of VRACs, showing its regulatory role is independent of aminopeptidase activity.

This study shows that the proton-activated chloride channel inhibits SARS-CoV-2 entry by blocking endosomal acidification and the cathepsin-dependent pathway.

This study identifies the proton-activated chloride channel as a regulator of phagosome maturation and bacterial killing in peritoneal macrophages, showing its role in immune responses.

The paper determines the structure of the TARP subunit γ2 using cryo-EM and identifies structural motifs that differentiate TARPs from claudins and explain subfamily variations.

This study shows that deletion of the proton-activated chloride channel in neurons leads to endosomal hyper-acidification, impairing AMPA receptor endocytosis and long-term depression.

This paper develops CytoCl dyes for real-time imaging of cytosolic chloride flux in live cells, revealing rapid changes and enabling first-time single-cell imaging of chloride channel activity.

This study identifies KAT6A's role in regulating synaptic plasticity and memory through RSPO2/Wnt signaling in hippocampal CA3, linking KAT6A deficiency to cognitive impairments.

This paper describes a new non-mosaic humanized mouse model of Down syndrome with a nearly complete copy of the long arm of human chromosome 21.