Alejandra Montaño Romero

This study shows memantine inhibits calcium-permeable AMPA receptors, revealing a new mechanism distinct from NMDA receptors and suggesting therapeutic potential for neurological disorders.

This study identifies ion permeation pathways in AMPARs using cryo-EM and MD simulations, showing how mutations affect ion flow and susceptibility to blockage.

The paper determines the structure of the TARP subunit γ2 using cryo-EM and identifies structural motifs that differentiate TARPs from claudins and explain subfamily variations.

This study reveals how negative allosteric modulators inhibit AMPA receptors by disrupting glutamate binding and outcompeting positive modulators, offering insights for therapeutic design.