Molecular BiologyNature Structural & Molecular BiologyPeer-reviewed
Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein.
Kazuhiro Kobayashi, Wataru Shihoya, Tomohiro Nishizawa…·Osamu Nureki
The paper presents a cryo-EM structure of the human PAC1 receptor bound to PACAP and an engineered Gs heterotrimer, revealing functional differences in the ECD between PAC1R and GLP1R.
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