Zeyu Zhu

This paper develops VADER, a virus-assisted directed evolution method for improving suppressor tRNAs in mammalian cells, resulting in more active and orthogonal tRNA mutants.

This paper introduces transcriptomic entropy as a generalizable predictor of bacterial fitness and antibiotic sensitivity across species and stress conditions using RNA-Seq and experimental evolution data.

This paper identifies mutations that alter fluoroquinolone sensitivity in Acinetobacter baumannii and shows that preferential Topo IV poisoning leads to prophage induction and SOS response activation.

This paper predicts bacterial survival and adaptive evolution using multi-omics data, network analysis, and machine learning to identify coordinated responses and gene adaptation.