Author

Megha Lal

Children's Hospital of PhiladelphiaORCID 0000-0002-9235-7255Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Jarad BeersiD· 3 shared Melanie A. RuffneriD· 3 shared Ravi GautamiD· 3 shared Zoe Mrozek· 3 shared Amanda B. MuiriD· 2 shared Margaret C. Carroll· 2 shared Tina TrachseliD· 2 shared Alyssa BaccarellaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersImmunology

Jarad BeersORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintOct 30, 2026

Systemic Analysis of Patient Derived Esophageal Epithelial Organoid Model Reveals Cell State Heterogeneity and Conservation of Differentiation Hierarchy

Alyssa Baccarella, Yusen Zhou, Tatiana A. Karakasheva…·Melanie A. Ruffner

The paper uses scRNA-seq to compare IL-13-treated esophageal organoids with EoE biopsies, revealing shared cell state heterogeneity and differentiation hierarchy dysregulation.

DOI 10.64898/2026.10.29.762343

humanscRNA-seq

𝕏 PostBluesky

ImmunologyPediatric Allergy and ImmunologyPeer-reviewedFeb 27, 2026

Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils

Ravi Gautam, Megha Lal, Margaret C. Carroll…·Melanie A. Ruffner

This study shows that omeprazole modulates esophageal epithelial barrier function and reduces eosinophil activation in an IL-13-induced model of eosinophilic esophagitis.

6 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologyCellular and Molecular Gastroenterology and HepatologyPeer-reviewedJan 1, 2025

Interferon-γ signaling in eosinophilic esophagitis has implications for epithelial barrier function and programmed cell death.

Megha Lal, Caitlin M. Burk, Ravi Gautam…·Melanie A. Ruffner

This study investigates interferon-γ signaling in eosinophilic esophagitis, showing its impact on epithelial barrier function and apoptosis in esophageal epithelial cells.

20 citationstop 1%

humanscRNA-seq

𝕏 PostBluesky