Melanie A. Ruffner

The paper uses scRNA-seq to compare IL-13-treated esophageal organoids with EoE biopsies, revealing shared cell state heterogeneity and differentiation hierarchy dysregulation.

This study shows that NIX-mediated mitochondrial remodeling is essential for esophageal epithelial differentiation and that its disruption may contribute to eosinophilic esophagitis.

This study identifies T cell dysregulation in pediatric obesity and shows that these changes persist despite weight loss.

This study shows that omeprazole modulates esophageal epithelial barrier function and reduces eosinophil activation in an IL-13-induced model of eosinophilic esophagitis.

This study identifies FOXM1 as a key driver of epithelial disruption in EoE, showing that its inhibition restores differentiation, reduces hyperplasia, and improves barrier function.

This study identifies IL-13 as a driver of increased mitochondrial mass in esophageal keratinocytes, impairing squamous cell differentiation and contributing to eosinophilic esophagitis.

This study investigates interferon-γ signaling in eosinophilic esophagitis, showing its impact on epithelial barrier function and apoptosis in esophageal epithelial cells.