Caitlin F. Harrigan

The paper introduces DAMUTA, a model that distinguishes DNA damage and misrepair processes in mutational signatures, showing improved resolution over existing methods in pan-cancer analysis.

The paper introduces a Bayesian optimization framework for automated registration of spatial expression data across modalities, achieving higher success rates on a large dataset of 954 image pairs.

This study shows that bacterial ADP-heptose triggers a revival stem cell program in the intestinal epithelium by inducing Paneth cell dedifferentiation and ISC loss.