Stephen E. Girardin

This study shows that NOD2 signaling in endothelial cells regulates intestinal immune responses by promoting T cell homing and memory formation, and its loss contributes to Crohn's disease inflammation.

This study shows that GSDMD pore formation stops caspase-4 activity to control IL-18 production in intestinal epithelial cells, preventing excessive inflammation.

This study shows that NLRP1B allele 2 in intestinal epithelial cells does not respond to VbP, unlike in macrophages, suggesting allele-dependent regulation in IECs.

This study shows that bacterial ADP-heptose triggers a revival stem cell program in the intestinal epithelium by inducing Paneth cell dedifferentiation and ISC loss.