Marco Saponaro

This study shows MYBL2 maintains stemness and promotes theta-mediated end joining in TNBC, and identifies Pol{theta}/ATR inhibition as a therapeutic strategy.

The paper shows that overexpression of RNA Polymerase II subunits correlates with poor cancer outcomes and induces genome instability through subunit-specific transcriptional changes.

This study identifies USP50 as a ubiquitin-binding protein that regulates helicase and nuclease activities during DNA replication to prevent fork collapse and maintain genomic stability.

This paper reports genome-wide ChIP data showing Upf1 associates with active genes in S. pombe, correlating with Pol II transcription and mRNA levels, and reveals transcriptional defects in Upf1-deficient cells.

This study identifies RPRD proteins as negative regulators of transcription in human cells, showing their inverse correlation with RNA accumulation and their role in forming complexes with Pol II.

This study shows BET inhibition causes replication stress through transcription-replication interference, involving HEXIM1 and RAD51, and reveals a new mechanism for BRD4's role in DNA replication and recombination.