Sophie J. F. van der Spek

The paper maps protein interaction network remodeling in a mouse tauopathy model using multi-omics and machine learning, identifying key complexes involved in early disease phenotypes.

The paper shows that loss of age-related m6A RNA methylation in Alzheimer's disease brains is linked to GABAergic dysfunction and synaptic issues.

This study shows TIA1 regulates divergent inflammatory responses in microglia and macrophages, reducing brain inflammation and tau pathology while increasing peripheral inflammation.

The paper uses proximity labeling to study the dynamic SQSTM1 protein network and shows that aggregated tau alters its interactions with stress-associated proteins.

The paper shows that ORF57 from Human Herpesvirus 8 reduces TDP-43 aggregation and cell death by interacting with ISR components.

The paper identifies synaptic gene sets that can discriminate cortical neuronal identities with the same power as all genes, revealing functional categories and compartments with cell type-specific expression.

This study shows that β-amyloid oligomers cause synaptic depression by removing GluA3-containing AMPARs from synapses, requiring PDZ protein interaction.