Xianming Deng

This study shows that aldometanib activates AMPK to enhance CD8+ T cell infiltration and control hepatocellular carcinoma growth in immune-competent mice.

This study develops a small-molecule degrader, XMU-MP-9, that promotes ubiquitination and degradation of K-Ras mutants, including K-RasG12V, by enhancing Nedd4-1 interaction with K-Ras.

This study identifies lithocholic acid as a metabolite that mimics calorie restriction's anti-aging effects in multiple species through AMPK activation.

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.