Robert Neil Kelsh

This paper introduces STERN, a framework that quantitatively compares developmental trajectories across embryos by learning spatiotemporal representations from 4D imaging data.

This study identifies DANCR as a conserved lncRNA essential for zebrafish development and a human melanoma oncogene, showing its role in regulating gene expression and promoting cancer progression.

The paper shows that Sox10 is required for systemic calcium uptake necessary for bone mineralization, through regulation of Stc1a production by neural crest cells.

This study shows that Pax3 and Pax7 work with Mitf to control melanophore and xanthophore development in medaka and zebrafish, revealing a conserved but complex regulatory network.

The paper shows that migratory identity and terminal differentiation of trunk neural crest cells are coordinated, with leader cells giving rise to distal derivatives and followers to Schwann cells.

This study shows Notch signaling controls cell cycle progression to define leader and follower identities during zebrafish Trunk Neural Crest migration.

The paper introduces mathematical models that generate oscillations in cell differentiation, proposing alternative mechanisms to the traditional epigenetic landscape framework.

This study uses single-cell transcriptomics to show zebrafish pigment cells develop directly from broadly multipotent progenitors, challenging traditional fate restriction models.

This study shows that differential growth, not initial pigment cell distribution, drives zebrafish stripe pattern formation and explains key developmental features.

This study identifies Tfec as the master regulator of iridophore fate specification from multipotent neural crest progenitors in zebrafish, revealing its role in early pigment cell lineage decisions.

This study shows zebrafish enteric glia can proliferate and generate enteric neurons, similar to brain neural stem cells, and are regulated by Notch signaling.

The paper identifies Endothelin receptor Aa as a regulator of APSC quiescence in zebrafish, linking blood vessel signals to pigment cell differentiation.

The paper identifies the core gene regulatory network (GRN) governing iridophore fate choice from neural crest progenitors in zebrafish using experimental data and mathematical modeling.