Claus M. Azzalin

This study characterizes TERRA and ARIA telomeric RNAs in CHO cells, showing ARIA regulates telomeric DNA integrity by preventing ssDNA formation at ITSs.

This paper identifies two distinct MUS81 inhibitors that enhance chemotherapy efficacy by impairing DNA repair in cancer cells.

The paper identifies PC4 as a novel factor essential for ALT cell viability, showing that its depletion causes ALT cell death and telomere fragility.

The paper introduces TERRA ONTseq, a long-read sequencing pipeline to study human TERRA, revealing widespread TERRA production and novel promoter regions.

This study shows that TET enzyme-mediated 5hmC formation promotes R-loop formation during transcription in stem cells, affecting gene expression.

This paper reports genome-wide ChIP data showing Upf1 associates with active genes in S. pombe, correlating with Pol II transcription and mRNA levels, and reveals transcriptional defects in Upf1-deficient cells.

This study investigates telomere maintenance in fission yeast lacking telomerase, showing that TERRA RNA and shelterin component changes support recombination-based telomere maintenance.