Xingzhi Song

This study compares spatial immune architectures in tumor and tumor-adjacent tissues of early-stage NSCLC, finding distinct immune cell densities, spatial patterns, and associations with genomic features and patient outcomes.

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

This study examines how allogeneic stem cell transplant affects subclonal evolution in chronic lymphocytic leukemia, identifying cellular homogeneity as a biomarker for immune response.

The paper introduces ICeITH, a Bayesian model to assess intratumor heterogeneity of tumor-infiltrating leukocytes using multi-region gene expression data, showing improved accuracy over existing methods.

This study identifies a prostate cancer-induced endothelial-to-osteoblast transition that creates an immunosuppressive bone tumor microenvironment, reducing the effectiveness of immune checkpoint therapy in bone metastatic castrate-resistant prostate cancer.

This study identifies distinct microbial subtypes in adenoid cystic carcinomas and links them to patient outcomes and tumor biology.

This study shows that transcriptomic features, not genomic characteristics, drive the histologic phenotype of lung cancers.

This study examines genomic and TCR repertoire heterogeneity in SCLC, finding that lower TCR heterogeneity and mutational burden correlate with better survival.

Flowr provides a robust, scalable, and portable framework for designing computing pipelines using a simple language-agnostic approach.