Bruce Stillman

The paper maps ORC1 binding sites across the human genome, linking replication licensing to chromatin states, 3D genome organization, and replication timing.

This study identifies CIZ1 as a scaffold protein that coordinates DNA replication licensing, Cyclin-CDK signaling, and chromatin organization, with its depletion inhibiting tumor growth in xenograft models.

The paper compares origin recognition mechanisms in yeast and human cells, revealing evolutionary differences in DNA replication initiation.

The paper presents high-quality genome assemblies and annotations for two Yarrowia lipolytica strains, using a combination of short-read and long-read sequencing technologies.

The paper shows Rad53 binds to gene promoters under replication stress, influencing gene expression and coordinating replication with transcription.

The paper identifies Cyclin-binding (Cy) motifs in ORC1 and CDC6 that mediate cell cycle-dependent protein interactions and regulate DNA replication initiation.

This study shows ORC subunits and CDC6 are essential for pre-RC assembly, mitosis, and nuclear structure in human cells.

The paper identifies sequence-specificity in DNA replication origins mediated by Orc4 α-helix in S. cerevisiae and links its evolution to gene silencing mechanisms.

The paper investigates the roles of Mcm4, Sld3, and Dbf4 in DNA replication origin activation and fork progression under various conditions.