Author
Universitätsmedizin GöttingenORCID 0000-0002-9462-1291Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Madeleine Dorsch, Felix E.G. Beaudry, Anna K. Baginska…·Barbara M. Grüner
This study identifies LOY as a driver of aggressive PDAC through epigenetic reprogramming, linking it to EMT and metastasis, and highlights its clinical relevance as a biomarker.
Kanishka Tiwary, Anton Lahusen, Syeda Inaas…·Patrick Christian Hermann
This study identifies a CXCL12/CXCR4/BMI1 signaling axis that promotes metastasis in PDAC via tumor-stroma crosstalk and shows that JM#21, a CXCR4 inhibitor, suppresses miCSCs and enhances chemotherapy efficacy.
Maj-Britt Paulsohn, Klara Henrike Frahnert, Xin Fang…·Matthias Dobbelstein
This study shows that combining KRAS and CDK4/6 inhibitors synergistically suppresses pancreatic cancer cells and organoids with KRAS mutations, with durable effects even after drug washout.
Lukas Klein, Mengyu Tu, Niklas Krebs…·Shiv K. Singh
The paper identifies AP1 transcription factor dichotomy and CD68+ macrophages as drivers of intratumoral subtype co-existence and therapy response in pancreatic cancer.
Emre Taylan Duman, Maren Sitte, Karly Conrads…·Gabriela Salinas
The paper develops a single-nucleus full-length RNA-sequencing approach to identify intronic variants linked to mis-splicing in pancreatic cancer.