MicrobiologybioRxivPreprint
Disassembly of the Escherichia coli AcrABZ-TolC efflux pump by ligand-mediated disruption of TolC-AcrA interfacial contacts
Tania Szal, Emmanouela Petsolari, Janis Veliks…·Björn Windshügel
The paper identifies a compound that disrupts the TolC-AcrA interface of the E. coli efflux pump, leading to pump disassembly and reduced antibiotic resistance.
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