BiochemistryAngewandte Chemie International EditionPeer-reviewed
Gas tunnel engineering of prolyl hydroxylasereprograms hypoxia signaling in cells
Peter K. Windsor, Haiping Ouyang, Joseph A. G. da Costa…·Ambika Bhagi‐Damodaran
This study reprograms hypoxia signaling by engineering PHD2 to enhance its catalytic efficiency, leading to reduced HIF-1 and hypoxia response transcripts under low oxygen conditions.
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