Brian K. Chung

This study introduces a co-aggregation method to improve morphogenesis and lineage representation in human stem cell-based embryo models.

The paper identifies ultra long-lived plasma cells in the human small intestine that produce IgA antibodies reactive to a diverse microbiota, suggesting long-term immune memory shaping the microbiome.

The paper describes a modular co-aggregation strategy to recreate embryonic-extraembryonic interactions in vitro, leading to more complex gastruloid morphotypes with improved lineage diversity and patterning.