Virginie Marcel

The paper analyzes translatome and translation dynamics in RiboCancer cell lines to show that Rps15 mutations disrupt tRNA accommodation, affecting translation efficiency and transcriptional regulation in CLL.

This study identifies ribosome biogenesis as a therapeutic vulnerability in TNBC, showing that inhibiting rRNA maturation via Fibrillarin or RNA Pol I reduces tumor growth without significant cell death.

SnoBIRD identifies and refines C/D box snoRNA annotations across eukaryotes by distinguishing expressed snoRNAs from pseudogenes.

The paper identifies a tranSNP in DDIT4 mRNA that affects translation efficiency and modulates p53-dependent responses in cancer cells.

This study investigates ribosome biogenesis as a therapeutic target in neuroblastoma, showing that inhibiting RNA polymerase I reduces cell proliferation and induces apoptosis.

The paper identifies SURF2 as a MDM2 antagonist that modulates nucleolar stress responses by buffering free-5S RNP particles, linking it to cancer resistance and patient survival.

The paper identifies a shared neoepitope from non-canonical c-MYC translation in cancer cells that activates T cells to kill tumors without harming normal cells.