Li Ma

The paper shows that endosome maturation is regulated by proton signaling through NHE6 and pH-dependent Rab7 cycling, with implications for neurodegeneration.

This study identifies GGA1 as an interacting partner of NHE6, showing that their interaction is critical for NHE6 localization to endosomes.

This paper corrects a pathogenic mutation in iPSCs from a Christianson syndrome patient using CRISPR/Cas9, resulting in functional NHE6 protein expression.

The paper uses iPSC-derived neurons from Christianson syndrome patients to show allele-specific responses to rescue strategies, highlighting the need for personalized therapeutic approaches.