Julie A. Moreno

This study shows that microglial NF-κB signaling is critical for prion disease progression, with IKK KO microglia leading to faster disease onset and neuronal loss.

This study shows that Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function in aged and tauopathy mouse models.

This paper demonstrates that inflammasome-inhibiting Nanoligomers reduce neuroinflammation and improve outcomes in an EAE mouse model of MS.

This paper evaluates the safety, pharmacokinetics, and biodistribution of an inflammasome-targeting Nanoligomer cocktail in small and large animals across multiple administration routes.

This paper shows that targeting neuroinflammation by down-regulating NF-κB and NLRP3 with SB_NI_112 protects against neurodegeneration in prion disease models.

This paper demonstrates that NI112, a brain-penetrant Nanoligomer targeting NF-κB and NLRP3, improves functional outcomes and reduces neuroinflammation in ALS and AD human organoid and mouse models.

This study shows that binge ethanol increases NLRP3+ microglia in aged mice, and that Nanoligomer therapy reduces ethanol-induced neuroinflammation and tau hyperphosphorylation.

The paper examines brain pathologies in aging canines with and without cognitive decline, finding that tau hyperphosphorylation at T217 may predict cognitive dysfunction.