Karine Guillem

This study shows that nicotine escalation in rats leads to increased drug-seeking and relapse vulnerability, with no significant sex differences.

This study investigates how neuronal activity in the ventromedial prefrontal cortex (vmPFC) changes with attention load and nicotine, finding distinct mechanisms for attention and gamma oscillations.

This study investigates the 5-CSRTT task in rats, finding that response accuracy reflects sustained attention while omissions indicate failure to attend to stimulus location.

This study shows that pre-existing attentional deficits predict nicotine intake escalation in rats, and withdrawal from nicotine causes attentional deficits that are reversed by acute nicotine.

The paper identifies brain regions associated with preference for sweet water over cocaine in rats using fos mapping, showing cocaine induces more global activation but saccharin activates regions related to taste and reward delay.

The paper identifies a mechanism in the orbitofrontal cortex of rats where the proportion of cocaine-coding neurons determines individual drug preferences.

This study shows that complete extinction of cocaine priming in rats does not prevent relapse, suggesting the presence of extinction-resistant behavior that contributes to relapse vulnerability.