PhysiologyJournal of Clinical InvestigationPeer-reviewed
Diet-induced obesity results in endothelial cell desensitization to VEGF-A and permanent islet vascular dysfunction
Yan Xiong, Andrea Dicker, Montse Visa…·Per‐Olof Berggren
This study shows that diet-induced obesity causes permanent vascular dysfunction in pancreatic islets by desensitizing endothelial cells to VEGF-A, impairing glucose homeostasis.