Per‐Olof Berggren

This study shows that diet-induced obesity causes permanent vascular dysfunction in pancreatic islets by desensitizing endothelial cells to VEGF-A, impairing glucose homeostasis.

The paper develops an MR-based brain template and atlas for optical imaging techniques, enabling anatomical mapping of fluorescent signals in cleared mouse brains.

This paper develops a baculovirus-based system for delivering large DNA cargoes for CRISPR-based genome editing in human cells, achieving up to 30% correct interventions.

The paper compares transcriptomic profiles of HEK293 cell lines producing erythropoietin or GFP to identify factors associated with improved erythropoietin production.

The paper shows that islet resident macrophages drive islet remodeling and hyperinsulinemia in early type-2 diabetes by promoting vascularization and insulin secretion.