Moritz Treeck

This study identifies FIKK1 as a kinase that phosphorylates VAR2CSA, enhancing its binding to CSA and promoting placental malaria virulence.

The paper shows that febrile heat stress increases cytoadhesion in Plasmodium falciparum-infected red blood cells by enhancing surface protein trafficking, including PfEMP1 and PSAC.

This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.

The paper identifies GRA12 as a critical secreted virulence factor in Toxoplasma gondii that functions across different parasite strains and mouse species.

The paper shows that MYR1-deficient Toxoplasma gondii mutants are rescued by co-infection with wild-type parasites in mice, revealing a limitation of pooled in vivo CRISPR screens.

This paper introduces dual perturb-seq, a method combining CRISPR screening and single-cell RNA-sequencing to identify host-microbe transcriptional interactions, revealing new effector proteins in Toxoplasma gondii.

The paper identifies WNG1, a divergent kinase in Toxoplasma, that regulates PV membrane ultrastructure through phosphorylation of PV-resident proteins.

This paper identifies a tyrosine transporter phosphorylated by TgCDPK3 in Toxoplasma gondii, showing its role in parasite fitness and metabolism beyond egress.