Martin J. Baker

This paper shows P-Rex1 limits agonist-induced GPCR internalisation through its PDZ, DEP, and IP4P domains, independent of its Rac-GEF activity, by inhibiting phosphorylation and interacting with Grk2.

This study compares KRASG12C and KRASG12D mutant NSCLC models, finding that KRASG12D relies more on the PI3K-AKT-mTOR pathway, suggesting tailored combination therapies.

The paper identifies intergenic duplications at Xq26.1 as the genetic cause of Bazex-Dupre-Christol syndrome, linking them to ARHGAP36 dysregulation and BCC susceptibility.