Hang Hubert Yin

This study characterizes the reverse transcription activity of DRT10 and reveals its unique 2:1 RT:ncRNA assembly and mechanism of cDNA synthesis.

This study characterizes the Ec78 retron system, revealing its dual-enzyme effector complex and the molecular mechanism of phage clearance through cryo-EM structures and functional analysis.

The paper identifies how cGAS is recruited to organelle membranes via phase separation, revealing a mechanism to regulate its activity and innate immune responses.

This study determines the cryo-EM structures of RNF168/UbcH5c-Ub/nucleosome complexes to elucidate the mechanism of H2A K13/K15 site-specific ubiquitination.

This study determines the cryo-EM structures of SIR2, HerA, and their complex, revealing their structural basis for antiphage activity and functional interactions.