Chemogenetic attenuation of PFC pyramidal neurons restores deficits in recognition memory following adolescent NMDA receptor blockade
Hagar Bauminger, Sailendrakumar Kolatt Chandran, Hiba Zaidan…·Inna Gaisler‐Salomon
This study shows that chronic MK-801 administration during early adolescence disrupts the E/I balance in the PFC, leading to recognition memory deficits, which can be reversed by chemogenetic attenuation of pyramidal neurons.