DdmDE eliminates plasmid invasion by DNA-guided DNA targeting
Xiaoyuan Yang, Zhangfei Shen, Chen Wang…·Tian‐Min Fu
This study elucidates the mechanism of the DdmDE system in eliminating plasmids through DNA-guided targeting and cleavage.
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The Ohio State UniversityORCID 0000-0002-9857-6010Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Xiaoyuan Yang, Zhangfei Shen, Chen Wang…·Tian‐Min Fu
This study elucidates the mechanism of the DdmDE system in eliminating plasmids through DNA-guided targeting and cleavage.
GeunYoung Sim, Audrey C. Kehling, Mi Seul Park…·Kotaro Nakanishi
The paper determines the minimum guide lengths required for miR-20a and let-7a to maintain their RISC conformation, finding 19 and 20 nt respectively, and identifies 17-nt guides as functional tinyRNAs (tyRNAs) without PAZ domain anchoring.
GeunYoung Sim, Audrey C. Kehling, Mi Seul Park…·Kotaro Nakanishi
The paper identifies manganese-dependent 3'->5' exonucleases that trim miRNAs to generate short tyRNAs, revealing their role in AGO3 slicer activity and gene silencing under stress conditions.