Fangyuan Chen

This study shows that ER-positive ILC xenograft models replicate metastatic patterns and endocrine response of human invasive lobular breast carcinoma.

The paper constructs a single-cell peripheral immune atlas for Black and White women across breast disease states, identifying race-associated immune differences linked to chronic inflammation and immune aging in Black patients.

This study benchmarks 12 scRNA-seq CNV inference methods across 28 datasets, finding allele-aware tools perform better with high-quality allelic data, while expression-centric tools are reliable with raw data.

This study identifies RET as a druggable target in estrogen receptor-positive breast cancer brain metastases and shows that Pralsetinib inhibits RET-driven metastatic properties.

EstroGene2.0 is a multi-omic database that compiles data on estrogen receptor responses and resistance in breast cancer, revealing diverse transcriptomic changes and identifying key targets.

This study identifies mDia2 as a mediator of MRTF-A-dependent breast cancer cell migration and links MRTF activity to malignancy, suggesting it as a therapeutic target.