ImmunologybioRxivPreprint
Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses
Selena Lorrey, Lucas P. Wachsmuth, John B. Finlay…·Peter Edward Fecci
This study shows that intracranial tumors cause systemic sympathetic hyperactivity, impairing T cell function and limiting immunotherapy, and that beta-adrenergic blockade improves outcomes in mouse models and human patients.