Yaakov Levy

The paper shows that intrinsically disordered regions in Drosophila Hox proteins affect the usage of conserved motifs near the homeodomain through context-dependent intramolecular interactions.

This study shows phosphorylation of IGF2BP1 and IGF2BP3 at a conserved serine acts as a configurational switch, altering their RNA binding domain arrangements and affecting mRNA regulation.

The paper determines the cryo-EM structure of the Lujo virus spike complex, revealing how it binds neuropilin-2 and providing insights for vaccine design.

This study uses single-molecule techniques to show that RPA partially wraps ssDNA and that phosphorylation at Ser-384 modulates this wrapping.

The paper identifies ORC elements that guide DNA binding in vivo, showing disordered basic patches are key for motif recognition at replication origins and silencing sites.

This study investigates RPA's long-distance migration on ssDNA using biophysical methods, finding that intersegmental transfer via multivalent interactions enables rapid diffusion under tension.

The paper presents an integrated structural analysis of intestinal mucin MUC2, revealing the shared mechanism of polymer formation for mucosal barriers and blood clotting.