Vikas Kaushik

This study shows phosphorylation of IGF2BP1 and IGF2BP3 at a conserved serine acts as a configurational switch, altering their RNA binding domain arrangements and affecting mRNA regulation.

This study investigates the interplay between DNA damage tolerance pathways by comparing PCNA occupancy and RPA/Rad51 exchange at stalled replication sites.

This study identifies a feedback mechanism involving Cdk1/Wee1 signaling that primes and tunes RPA phosphorylation, crucial for cell cycle progression and DNA damage response.

This study reveals how Rad52 sorts and stacks Rad51 at DNA junctions to enhance homologous recombination by promoting Rad51 binding to RPA-coated ssDNA.

This study uses single-molecule techniques to show that RPA partially wraps ssDNA and that phosphorylation at Ser-384 modulates this wrapping.

This study investigates RPA's long-distance migration on ssDNA using biophysical methods, finding that intersegmental transfer via multivalent interactions enables rapid diffusion under tension.

This paper describes fluorescently modified human RPA to study its dynamic interactions with ssDNA and other proteins.